By Nick Eagles
Over the past few years, I’ve had the opportunity to work with a lot of whole-genome bisulfite-sequencing (WGBS) datasets. They provide a powerful opportunity to look at DNA methylation on a complete scale, in contrast to microarrays which target a narrower set of important CpG sites across the genome. But for this same reason, the data is often unwieldy, and can feel difficult to tackle even with access to powerful computational resources.