Given an input set of genomic coordinates, this package builds a RangedSummarizedExperiment object by extracting the base-pair coverage from the scaled BigWig files for a set of LIBD projects. The RSE object contains the read counts for a library size of 40 million 100 bp mapped reads.

This package provides a comparable result to recount::coverage_matrix() does for the over 70,000 human RNA-seq samples available through the recount2 project. libdRSE provides an interface to the BigWig files from the public LIBD RNA-seq projects. Check the recount workflow for more information on the process of counting expression from BigWig base-pair coverage files.